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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutrition, Psychology and Brain Health
doi: 10.3389/fnut.2022.996692
This article is part of the Research Topic

Key nutrition and hydration insights for Public Health and Policy

View all 24 Articles

Nutrient combinations exhibit universal antianxiety, antioxidant, neuro-protecting and memory-improving capabilities

Bangcheng Zhao1, Xiuzhen Jia2, Haotian Feng2, Cheng Tang3, Yixin Huang4, Zifu Zhao2, Jingyu Hao2, Haoqiu Li2, Jinrui Du2, Yan Liu2, Xingyu Bao2, Zhihui Zhong1, Yingqian Zhang1, 5* and Qixing Zhong1, 3*
  • 1Laboratory of Nonhuman Primate Disease Modeling Research, State Key Laboratory of biotherapy, West China Hospital, Sichuan University,, China
  • 2nner Mongolia Dairy Technology Research Institute Co. Ltd.; Yili Innovation Center, Inner Mongolia Yili Industrial Group Co., Ltd., Hohhot 010110, China, China
  • 3Sichuan SAFE Pharmaceutical Technology Co. Ltd, China
  • 4Hunan Agricultural University, China
  • 5Sichuan Kangcheng Biotech Co., Inc., China
Provisionally accepted:
The final, formatted version of the article will be published soon.

Anxiety disorders are the most common mental disorders and, without proper treatment, may lead to severe conditions: e.g., somatic disorders or permanent damage to central nervous system. Although there are drugs in clinical trials, this study focuses on exploring the efficacy of nutrients in treating these diseases. We built different zebrafish models and screened several nutrient combinations for their antianxiety, antioxidant, neuro-protecting and memory-improving activities. Our results showed that the combinations of nutrients (e.g., Walnut Peptides + Theanine at 14.2 + 33.3 μg/mL) have similar or better activities than the positive control drugs. In addition, we discovered that the effects of the nutrients in the above four aspects were universal and highly related. This study is noteworthy as it suggested that nutrients could be healthier and greener drug alternatives and provide similar or better universal treatments for anxiety and related conditions.

Keywords: Nutrients, Zebrafish, Antianxiety, antioxidant, Neuroprotection, Memory-improving

Received:18 Jul 2022; Accepted: 14 Dec 2022.

Copyright: © 2022 Zhao, Jia, Feng, Tang, Huang, Zhao, Hao, Li, Du, Liu, Bao, Zhong, Zhang and Zhong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Dr. Yingqian Zhang, Laboratory of Nonhuman Primate Disease Modeling Research, State Key Laboratory of biotherapy, West China Hospital, Sichuan University,, Chengdu, Sichuan Province, China
Dr. Qixing Zhong, Laboratory of Nonhuman Primate Disease Modeling Research, State Key Laboratory of biotherapy, West China Hospital, Sichuan University,, Chengdu, Sichuan Province, China